No association between polymorphisms in CYP2E1, GSTM1, NAT1, NAT2 and the risk of gastric adenocarcinoma in the European prospective investigation into cancer and nutrition.
نویسندگان
چکیده
Antonio Agudo,1 Núria Sala,2 Guillem Pera,1 Gabriel Capellá,3 Antonio Berenguer,1 Nadia Garcı́a,2,3 Domenico Palli,4 Heiner Boeing,5 Giuseppe Del Giudice,6 Calogero Saieva,4 Fatima Carneiro,7 Franco Berrino,8 Carlotta Sacerdote,9 Rosario Tumino,10 Salvatore Panico,11 Göran Berglund,12 Henrik Simán,12 Roger Stenling,13 Göran Hallmans,14 Carmen Martı́nez,15 Pilar Amiano,16 Aurelio Barricarte,17 Carmen Navarro,18 Jose R. Quirós,19 Naomi Allen,20 Tim Key,20 Sheila Bingham,21 Kay-Tee Khaw,21 Jakob Linseisen,22 Gabriele Nagel,22 Kim Overvad,23 Anne Tjonneland,24 Anja Olsen,24 H. Bas Bueno-de-Mesquita,25 Hendriek C. Boshuizen,26 Petra H. Peeters,27 Mattijs E. Numans,27 Françoise Clavel-Chapelon,28 Marie-Christine Boutron-Ruault,28 Antonia Trichopoulou,29 Eiliv Lund,30 Hendrik Bläker,31 Mazda Jenab,32 Pietro Ferrari,32 Teresa Norat,32 Elio Riboli,33 and Carlos A. González1
منابع مشابه
Study of cyp2E1 gene RsaI/PstI polymorphisms in patients with gastric cancer in north of Iran
Background: North of Iran is amongst high incidence rate areas of gastric carcinoma where environmental carcinogenic compounds especially agricultural pesticides are massively used. Cytochrome P450 2E1 (CYP2E1) enzyme metabolically activates a large number of low molecular mass xenobiotics. The polymorphic nature of cyp2E1 gene control elements is associated with interindividual differences...
متن کاملArylamine N-acetyltransferase 1 (NAT1) and 2 (NAT2) polymorphisms in susceptibility to bladder cancer: the influence of smoking.
Aromatic amines are involved in the etiology of bladder cancer. These compounds are acetylated by N-acetyltransferase 1 (NAT1) and 2 (NAT2), and epidemiological studies have shown that the slow NAT2 acetylator phenotype is associated with increased risk of bladder cancer and may be associated with decreased risk of colorectal cancer. By using PCR-RFLP analyses to identify three known slow acety...
متن کاملNo modifying effect of NAT1, GSTM1, and GSTT1 on the relation between smoking and colorectal cancer risk.
Introduction Cigarette smoke contains potent carcinogenic compounds, including polycyclic aromatic hydrocarbons, heterocyclic amines, and nitrosamines. When entering the body, cigarette carcinogens have relatively weak mutagenic potential. After being metabolized, more potent mutagens are formed, which could result in DNA adduct formation. The genes involved in this metabolism include NAT1, NAT...
متن کاملGenetic polymorphism of xenobiotic metabolising enzymes, diet and cancer susceptibility.
There is increasing evidence identifying the crucial role of numerous dietary components in modifying the process of carcinogenesis. The varied effects exerted by nutrient and non-nutrient dietary compounds on human health and cancer risk are one of the new challenges for nutritional sciences. In the present paper, an attempt is made to review the most recent epidemiological data on interaction...
متن کاملPolymorphisms of glutathione-S-transferase and arylamine N-acetyltransferase enzymes and susceptibility to colorectal cancer.
BACKGROUND Glutathione-S-transferases (GSTs) and N-acetyltransferases (NATs) are involved in the metabolism of a wide range of carcinogenic chemicals. Allelic polymorphism of these enzymes is associated with variations in enzyme activity, hence it may affect the concentration of activated carcinogenic chemicals in the body. Previous studies suggest a possible cancer risk-modifying effect of the...
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عنوان ژورنال:
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
دوره 15 5 شماره
صفحات -
تاریخ انتشار 2006